Effect of Bone Marrow Composition Changes With Age

Effect of Bone Marrow Composition Changes With Age PROJECT TOPIC: INVESTIGATION INTO THE EFFECT OF BONE MARROW COMPOSITION CHANGES WITH AGE BETWEEN THE TWO GENDERS ON FINE STRUCTURE ANALYSIS (FINESA) TECHNIQUE A short 100 word lay-person summary– The project is about the investigation into the bone marrow composition changes with age between the two genders and its effect on the structure MRI technique fineSA. It utilizes MR to excite the rectangular prism shape volume in the human body to generate a signal that is processed to provide information about anatomical structure of interest. It will be conducted in a 12 weeks period commencing with literature review of relevant journals and conference papers relating the topic. It will be followed by the modelling of a bone marrow phantom aimed at adding a uniform composition structure that will control the outcome of the project. It will then be concluded with the analysis of the processed clinical data for both genders with different age range. Aim The main aim of this project is to identify a trend between different gender subjects with a varying range of ages from 18-80 and other measures of signal which can be attributed to bone marrow composition and its effect on the fineSA technique. FineSA is a technique that defines anatomical structures using MR data by acquiring data from rectangular prisms located in the anatomical region and region of interest. It is currently unknown what happens to the fineSA in regards to bone marrow (BM) changes. By identifying the trend it will enable the technique to be adjusted to suit each subject and not generalise its bone marrow applications as it is currently done. The research will fill a gap in the industry concerning the bone marrow composition (BMC) changes with ages with the use of the fineSA techniques. Objectives Carry out a detailed literature research related to BMC changes with age and sex. Relevant journals and conference papers will be analysed to support the research work. The modelling of a bone marrow phantom to observe the effect of fat will be accomplished. The fluid around the phantom will simulate the bone marrow and that will give the signal expected. Analysis and evaluation of a clinical data set for different gender ages ranging 18-80 will be carried out. It will be started by looking at the k0 on the spectra with respect to the age and the expected bone marrow composition. The data obtained from the company is made of spectra in Matlab format and the relevant information will be extracted in Matlab. It will also be necessary to investigate the effect of noise as noise is measured during the acquisition. Resources and necessary approvals I will need to complete Human Subjects Protection training in order to work with patient data. It is used to fulfil the requirement for education in the protection of human subjects. The ethical review board that approved this study is Western Institutional Review Board (WIRB) located in the USA. There are no known health risks associated with this research. Literature review According to the literatures, bone marrow does changes with age and becomes fatty and so it is expected to give a higher signal in the MR technique used. According to an early studies conducted, for daughters and their parents to compare (BMF) content assessed by inphase and out-of-phase MRI in between family members. It was found that the daughters had less BMF and BM whole body and regions where BMF was assessed than their mothers and fathers. This was in agreement with a previous studies that link increased BMF with age [1]. MR spectroscopy studies have demonstrate that vertebral fat content increases as the bone density (BD) decreases. Several literatures have suggested a relationship between bone mineral content and bone marrow fat (BMF) which has been found to lead to bone weakness. A study was conducted on fifty-six female patients with the age range 50–65 years to assess vertebral bone marrow fat (BMF) content’s relationship with osteoporosis by the use of chemical-shift magnetic resonance imaging (CS-MRI). It was however concluded that BMF content calculated with CS-MRI was not reliable for predicting bone mineral density in female patients aged between 50 and 65 years and so further research was recommended [2]. Differences in the relationship between BMF and bone has also been attributed to the potential ethnic differences in African American and Caucasian men and women. This was shown in a study done to evaluate the relationship between BMAT and BMD for potential sex and ethnic differences within a large sample with DXA and whole-body MRI data. The results obtained was found to be consistent with a previous findings done in Caucasian women and of Asian men and women. However there is reported inverse association between BMF and BMD in studies of men and women without ethnicity explicitly [3]. A further study conducted on 211 subjects also suggested that BMC changes are different for both male and female subjects. The largest change in the BMC in the lumbar spine was seen to have occurred from 5 to 24 years in the male subjects. Conversely, the largest decrease occurred after 45 years in female subjects. In an earlier research by Dunnill et al. [4] to investigate the changes in cellular and BMF in the vertebral bodies and correlate those changes with age and sex, no differences between the sexes for age-related variations was found. This also implied more research need to be done to ascertain the relationship between BMC and age and sex [5]. Methodologies The project will be managed with the aid of programme of work with details on a Gantt chart that list all the tasks dates. The milestones mark the completion of a task and meetings with the supervisor for review. Literature research (2 week) A review of relevant literatures in relation to BMC changes with age and gender. Outcome 1: Literature review finished and theories for further research have been studied. Phantom Modelling (2 week) Arrangement will be made with the company for this to be carried out Outcome 2: Pantom modelled and analysed. Data analysis and evaluation (3 week) The clinical data will be analysed will be carried out at this stage and then evaluated. Outcome 3: Data analysed and a conclusion drawn. Draft write up (2 week) Write the first draft of the dissertation which will be presented to the research supervisor for review. Outcome 4: Complete first drafted of the report. Final dissertation (2 week) The final copy will be produced and reviewed for any errors and ethical issues by supervisor and then submitted. Outcome 5: Complete the final report for submission. Contingency (1 week) This is an open period where any problems encountered will be dealt with. Conclusion The research plan was conducted to evaluate the purpose and methodologies that will be employed for the project to be successful. With the timelines drafted and the resources effectively utilised the project is expected to be successful. At the end of the project, the results should guide the industry in use of the fineSA with bone marrow composition changes with age application. If it is concluded that there is a trend in the bone marrow composition changes with age, it will require changes made to the technique used in acquiring the signals. This could lead to having to adjust for composition the current technique used.

Equality: The Destination Yet To Be Reached :: essays research papers

He had a dream. Does anything else come to mind when you mention the one and only Martin Luther King Jr.? For most people, probably not. The truth is, King was recognized primarily for his dream. And why not? It was a good dream, one that promoted peace and equality. It was the dream that was thought to have united the black and white communities, the dream that made America aware of a problem, and the dream that ultimately led to his demise. Let me ask you a question: Would King be happy to see how far his dream has come? Don’t answer so quickly. Instead, let us ponder†¦ Today, there is coracial education. African Americans are in every U.S. school; it’s not uncommon. Blacks and whites can dine together at neighboring tables at any restaurant. Anyone to utter the word â€Å"nigger† is most definitely punished in the harshest form. Caucasians are not considered to be better than their darker friends in any way, shape, or form. Of the ignorant bigoted percentage of the population, whites consider blacks every bit as strong and honorable as themselves. Our schools even hold assemblies to reprimand racism, targeting these horribly self-emulating whites. For the most part, blacks have surpassed the label of â€Å"lower class,† or â€Å"uneducated,† or â€Å" secondary citizens.† For the most part, African Americans have overcome. But have they surpassed and overcame even equality itself? Dr. Martin Luther King Jr. fought for equality goes both ways. Just as it is unthinkable to place a white person above a black person, it should be unthinkable to place a black above a white. Perhaps it is the white community’s guilt or regret for years of oppression that accounts for this, but there is a growing amount of reversed racism in our country today. There are more cases where blacks are being treated differently, being treated special, simply because they are a few shades darker. White children have less oppertunities as a result of this. This is discrimination based on skin color. Is this not racism? The very racism King fought against? If we are all to be treated equally, as stated by our own government, then why is our government promoting the defiance of this very law? Colleges all across our country are responsible for practicing reversed racism. Because of their desire to accept students within a minority, they are in fact excluding many more qualified white students from their education services. Equality: The Destination Yet To Be Reached :: essays research papers He had a dream. Does anything else come to mind when you mention the one and only Martin Luther King Jr.? For most people, probably not. The truth is, King was recognized primarily for his dream. And why not? It was a good dream, one that promoted peace and equality. It was the dream that was thought to have united the black and white communities, the dream that made America aware of a problem, and the dream that ultimately led to his demise. Let me ask you a question: Would King be happy to see how far his dream has come? Don’t answer so quickly. Instead, let us ponder†¦ Today, there is coracial education. African Americans are in every U.S. school; it’s not uncommon. Blacks and whites can dine together at neighboring tables at any restaurant. Anyone to utter the word â€Å"nigger† is most definitely punished in the harshest form. Caucasians are not considered to be better than their darker friends in any way, shape, or form. Of the ignorant bigoted percentage of the population, whites consider blacks every bit as strong and honorable as themselves. Our schools even hold assemblies to reprimand racism, targeting these horribly self-emulating whites. For the most part, blacks have surpassed the label of â€Å"lower class,† or â€Å"uneducated,† or â€Å" secondary citizens.† For the most part, African Americans have overcome. But have they surpassed and overcame even equality itself? Dr. Martin Luther King Jr. fought for equality goes both ways. Just as it is unthinkable to place a white person above a black person, it should be unthinkable to place a black above a white. Perhaps it is the white community’s guilt or regret for years of oppression that accounts for this, but there is a growing amount of reversed racism in our country today. There are more cases where blacks are being treated differently, being treated special, simply because they are a few shades darker. White children have less oppertunities as a result of this. This is discrimination based on skin color. Is this not racism? The very racism King fought against? If we are all to be treated equally, as stated by our own government, then why is our government promoting the defiance of this very law? Colleges all across our country are responsible for practicing reversed racism. Because of their desire to accept students within a minority, they are in fact excluding many more qualified white students from their education services.

Choose a Topic from Your Personal Knowledge and Experience Essay

My whole wedding planning experience and the day I got married July 4, 2008 are the most memorable days of my life. The reason for choosing July 4 was because that was the day we became girlfriend and boyfriend. I realized it was time to get married after observing my boyfriend and getting to know him better, I decided he was the one with whom I wanted to share the rest of my life with. It was during the month of March when we picked out our wedding date. I noticed the time was nearing so quickly. Finally time to start planning. First I made an appointment with David’s Bridal to try on wedding dresses. One day while my husband was out working my best friend offered to take me. I then looked through a catalog and marked my favorite dresses. I am a very picky person. So I wanted my wedding dress to be the perfect one. I like to take my time in order to make a good decision. The Lady who brought out the dresses wasn’t helping much. It seems like she really didn’t care and I could walk out with any dress as long as she made a sale. I really liked one dress a lot. But it was time to go my appointment was over. I still wanted to try on more dresses just in case there was another dress way over the top beautiful. The lady said if I wanted to try on more dresses I should make another appointment. I finally left with a dress in mind. My next plan was to decide on where I wanted to get married. I began to do some local research on the Internet. I wrote down numbers and called. They were either all booked out or closed on July 4. I finally got too frustrated that I was thinking about canceling all my plans for a wedding and take a trip to the courthouse instead. No hassles and stress free is the way to be. I still wanted a wedding dress even to get married at the courthouse. I still wanted something special for us even though it was going to be the two of us. A few months went by getting closer to the date. One day my husband and I were taking care of errands when we pass a place that turns out to be a place to have a wedding. So we go check it out and really loved the place. It made us change our mind to have a wedding. A few days later I went into a store to look around at wedding stuff. There was a lady there that introduced me to her. Her name was Patty. She was really nice and really cared it turns out she does photography, catering makes cakes and more. Everything I needed. So one day my husband and I were driving around and I see this big yellow sign from the road. I tell him to turn around to see what it said. It was a big beautiful mansion. That read weddings, parties and graduations. We go in  there the lady shows the package plans available and gives us details. We were sitting with her at a round table. She just starred at us with those eyes that say sign the contract already. It didn’t seem like she realized that it was a big step to take. A lot of money and a lot of things to think about. We talked about it and decided to take the offer only 4 days left until July 4. We told my family about it and my mom was thrilled. On the other hand my grandma was saying we couldn’t plan a wedding in four days. Even though I was telling her I already paid for it and signed the contract. She thought it was too impossible for me. The lady patty told me from the store she could be my photographer. She also made my bouquet for me. My husband took me back to David’s bridal. I invited my two sisters to come along. I tried on a few more dresses while my husband stayed out in the car. He can’t see me until our wedding day of course. I picked out my necklace, earrings, and tiara. My sister bought me a veil as a wedding gift. I was ready to check out. I ended up buying the dress I liked from the first appointment. My husband and I went to look for rings that same day we went to zales. A lot of rings to choose from and I was stuck between two favorites. I finally picked out the one I liked so did my husband. Except I did something different he bought me an engagement ring to be my wedding ring. I like them better. We bought the rings and I decided 4 years ago Report Abuse Additional Details So we had to come pick it up another day. We were worried it wouldn’t be ready on the day of our wedding, But unfortunately it was. We went to the wedding rehearsal it was just me and him. My husband doesn’t speak english. So we practiced him saying the vowels. We decided he would just repeat after the minister on the actual wedding day. He sounded just like an american speaking. We then went over the walk one time and she said we were done. I expected more practice than that. I thought you practiced until you got it all down. This was our first experience and she didn’t even let us practice enough to get the feel. Well we finally left very worried with no good rehersal. I got some copies of the directions from map quest. I told my family about the wedding event. And where it would take place. I don’t know why but everyone was making up lame excuses. My Grandma said she couldn’t  drive in the dark. My aunt said there would be too much traffic. 4 years ago  to leave my ring with Zales to get it sized. My appointments turned out to be a disaster. So many things went wrong that it’s not even funny. The lady that waxed my eyebrows messed them up so badly. She left unwanted hairs everywhere. Then I made a spray tan appointment. I was supposed to start noticing change in the color of my body in two hours. I was so dissapointed there wasn’t even a difference. It was finally time to go pick up our rings. My ring was yellow it looked fake. I got upset started crying because the ring was so expensive and I wasn’t happy with it. I complained to them about the yellow ring. Thank God I had two favorites. I asked them if they could switch it out for the other one I liked. I felt so relieved when they said yes I could switch. Then they gave us a little bad news. They said when they were in the process of sizing the ring it shredded. They said it was a bad ring. They had to get him another ring but the same one and resize it again. 4 years ago A few other members in my family were coming up with excuses. That was really odd. My family was not supportive at all except all my sisters. My husband had to pay for the whole wedding. I didn’t even get any gifts. Now July 4, 2008 is finally here. I got my hair and makeup done by this old lady. She didn’t seem like she really cared either she just did an up do the way she liked it. She was also in a huge rush. She used makeup from the 1960’s literally. I could have done the work she did and better with the money she charged me. I started to get so emotional because I expected to look stunning. So here I am crying makeup and all. I got to my sister’s house looked in the mirror and said to myself not so bad after all. Did a few touch ups. Once I get my dress on everything will be all right. As random strangers tell me congratulations I’m starting to feel good. So here I am in shorts a t-shirt and wedding veil driving myself to my on wedding. 4 years ago It was about a forty minute drive. I only had about twenty minutes to get my dress on and have time to actually think. Well what do you know my sister forgot one of my under garments. So I had to wait for my husband to bring it  to me. He wasn’t even on his way yet. I should have already been in my dress. I put a few curls in my hair. It was time for it to start. My photographer got there with my beautiful twenty four red roses bouquet. She snapped a few pictures of me. Going down the staircase before anyone had seen me. So I’m walking down the aisle and I see my husband standing waiting for me. We said our vowels. We finally kissed I will always remember when he said to me â€Å"You look beautiful†. Everything turned out miraculously. Even though we had no idea what we were doing it all fell into place. It looked like we knew what we were doing and have already been married four times. 4 years ago You see through my wedding experience the planning and appointments can get stressful. Even though my family was not supportive they came to my wedding. I didn’t really care even if it was just going to be the two of us. I really showed my family I could do it. Nobody really cared but my photographer. She was the one telling us what to do even though it was not her job. To this day my Grandma’s always talking about how beautiful my wedding was. She always asks if she could borrow my pictures to show them off to people. Like at church work and family that didn’t get to come. So have faith in your wedding. As long as you and your other half stick together and believe everything will turn out great.

Illegal Immigrants Close the Borders Essay - 1317 Words

Illegal immigration has been a problem that has plagued the United States for many years. This problem is not new to the country because thousands of immigrants have crossed over the oceans and Mexican border since our country was founded. The underlying problem is the lack of assimilation to the American ways of life and the acceptance of existing rules and laws. With the already fragile economy and the largely growing unemployment rate Americans must make every effort to close its borders to undocumented workers to ease the strain and retain any available jobs for unemployed Americans and legal workers. Aviva Chomsky writes â€Å"immigration plays a much more complex role in the employment picture, and many different factors affecting†¦show more content†¦Ã¢â‚¬Å"of 147 illegal immigrants arrested by federal authorities in 1975 who re-entered the labor force, 35% received unemployment benefits at some time over the next five years.†(Anzovin 49) However, more recently illegal immigration has finally met with some opposition in some states such as Arizona, and Georgia with the passing of new legislation to crack down on illegal immigrants’ in these states. Until recently the illegal immigrants’ population in Georgia had increased every spring due to the fact that illegal workers move north from Florida after agricultural labor jobs run out at the end of harvesting season. But with the new immigration laws that have taken place in some states such as Georgia and Arizona it allows local law enforcement to see if a worker is legally able to work in the US. If the workers are illegal they are immediately deported and the employer that hired them is charged fine in excess of 270,000 dollars or more. All be it, the laws are more lax in my home state of Georgia than Arizona, I’m glad to see that the state has made some effort to battle the affliction facing the state and the country. One major difference in th e Georgia version of the law is that he citizen status is on to be check if one has been in the act of breaking the law where as in Arizona there only needs to be suspicion of immigration status to constitutes a status check. Part of that law states no employer may refuse to hire a qualified personShow MoreRelatedImmigration : The United States1087 Words   |  5 Pagescountry prospect and is more enrich. Opening the border might improve the economy or can impact the job market for American citizens. It is the jobs of American citizens to be given more to this illegal immigrant. I believe the U.S. borders should remain closed. 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